Yes. The State requires a license for each physical location. Also, a Special Event license is required for sales at locations “other than your normal place of business.” There is a fee for both types of licenses. You can download state applications from their website: www.colorado.gov/revenue/tax.
The State will provide a sales tax return for remittance of the State Sales Tax, RTD, and Cultural District Tax. DO NOT send the "FlatIron Improvement District" tax or the "Arista Local Improvement District" tax to the State of Colorado.
For a better understanding of the State of Colorado rules, please attend a State seminar. Go to: www.colorado.gov/revenue/tax for a listing of State Sales Tax Seminars.